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基因體暨生物資訊學研究所 助理教授

Dr. Liu, Jyung-Hurng 劉俊宏 博士

結構生物資訊學實驗室

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研究著作

[English version]

Google Scholar ORCID iD iconhttps://orcid.org/0000-0002-7173-0372
  1. Liu, J.-H.*, Yang, J.-Y., Hsu, D.-W., Lai, Y.-H., Li, Y.-P., Tsai, Y.-R. and Hou, M.-H. (2019, Oct.) Crystal structure-based exploration of arginine-containing peptide binding in the ADP-ribosyltransferase domain of the type III effector XopAI protein. Int. J. Mol. Sci. 20, 5085. doi: 10.3390/ijms20205085
    (SCI, IF 2018=4.183; Times cited: 0)
    *Corresponding author [PubMed] [IJMS] [PDB] [Proteopedia]
  2. Fang, Y.-T., Lai, W.-S., Liu, J.-H.* and Liu Y.-C.* (2018, Nov.) Enhanced cecropin B2 production via chitin-binding domain and intein self-cleavage system. Biotechnol. Appl. Biochem. 66, 209-15. doi: 10.1002/bab.1716
    (SCI, IF 2018=1.559; Times cited: 0)
    *Co-corresponding authors [PubMed] [BAB]
  3. Huang, M.-R., Hsu, Y.-L., Lin, T.-C., Cheng, T.-J., Li, L.-W., Tseng, Y.-W., Chou, Y.-S., Liu, J.-H., Pan, S.-H., Fang, J.-M. and Wong, C.-H. (2018, Nov.) Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer. Eur. J. Med. Chem. 181, 111551. doi: 10.1016/j.ejmech.2019.07.054
    (SCI, IF 2018=4.833; Times cited: 0) [PubMed] [EJMC]
  4. Shen W.-F.*, Galula J.-U.*, Liu, J.-H.*, Liao, M.-Y.*, Huang, C.-H., Wang, Y.-C., Wu, H.-C., Liang, J.-J., Lin, Y.-L., Whitney, M.T., Chang, G.-J., Chen, S.-R., Wu, S.-R. and Chao, D.-Y. (2018, Oct.) Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibody. eLife 7, e38970. doi: 10.7554/eLife.38970
    (SCI, IF 2018=7.551; Times cited: 2)
    *Co-first authors [PubMed] [eLife]
  5. Chiu, H.-C., Huang, W.-R., Liao, T.-L., Chi, P.-I., Nielsen, B.L., Liu, J.-H. and Liu H.-J. (2018, Jun.) Mechanistic insights into avian reovirus p17-modulated suppression of cell cycle CDK-cyclin complexes and enhancement of p53 and cyclin H interaction. J. Biol. Chem. 293, 12542-62. doi: 10.1074/jbc.RA118.002341
    (SCI, IF 2018=4.106; Times cited: 3) [PubMed] [JBC]
  6. Lee, C.-Y., Lin, C.-C., Liu, Y.-L., Liu, G.-Y.*, Liu, J.-H.* and Hung, H.-C.* (2017, Feb.) Molecular interplay between the dimer interface and the substrate-binding site of human peptidylarginine deiminase 4. Sci. Rep. 293, 12542-62. doi: 10.1074/jbc.RA118.002341
    (SCI, IF 2018=4.011; Times cited: 4)
    *Co-corresponding authors [PubMed] [Sci Rep]
  7. Li, C., Liu, J., Shaozhou, W., Bai, X., Zhang, Q., Hua, R., Liu, J.-H.*, Liu, M. and Zhang, Y.* (2016, Nov.) Epitope identification and application for diagnosis of duck Tembusu virus infections in ducks. Viruses 8, 306. doi: 10.3390/v8110306
    (SCI, IF 2018=3.811; Times cited: 8)
    *Co-corresponding authors [PubMed] [Viruses]
  8. Li, C., Bai, X., Meng, R., Shaozhou, W., Zhang, Q., Hua, R., Liu, J.-H., Liu, M. and Zhang, Y. (2016, Nov.) Identification of a new broadly cross-reactive epitope within domain III of the duck tembusu virus E protein. Sci. Rep. 6, 36288. doi: 10.1038/srep36288
    (SCI, IF 2018=4.011; Times cited: 6) [PubMed] [Sci Rep]
  9. Kuo, T.-C., Li, L.-W., Pan, S.-H., Fang, J.-M., Liu, J.-H., Cheng, T.-J., Wang, C.-J., Hung, P.-F., Chen, H.-Y., Hong, T.-M., Hsu, Y.-L., Wong, C.-H. and Yang, P.-C. (2016, Sep.) Purine-type compounds induce microtubule fragmentation and lung cancer cell death through interaction with Katanin. J. Med. Chem. 59, 8521-34. doi: 10.1021/acs.jmedchem.6b00797
    (SCI, IF 2018=6.054; Times cited: 9) [PubMed] [JMC]
  10. Chen J.-C., Liu, J.-H., Hsu, D.-W., Shu, J.-C., Chen, C.-Y. and Chen, C.-C. (2015, Sep.) Methylatable signaling helix coordinated inhibitory receiver domain in sensor kinase modulates environmental stress response in Bacillus cereus. PLoS One 10, e0137952. doi: 10.1371/journal.pone.0137952
    (SCI, IF 2018=2.776; Times cited: 3) [PubMed] [PLoS One]
  11. Hsieh, J.-Y., Li, S.-Y., Tsai, W.-C., Liu, J.-H., Lin, C.-L., Liu, G.-Y. and Hung, H.-C. (2015, Aug.) A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence. Oncotarget 6, 20084-98. doi: 10.18632/oncotarget.3907
    (SCI, IF 2016=5.168; Times cited: 5) [PubMed] [Oncotarget]
  12. Lin, H.-Y., Liu, J.-H., Cheng, K.-L., Lin, J.-Y., Liu, N.-R. and Meng, M. (2015, Jul.) A novel binding of GTP stabilizes the structure and modulates the activities of human phosphoglucose isomerase/autocrine motility factor. Biochem Biophys Rep. 2, 14-22. doi: 10.1016/j.bbrep.2015.04.003
    (Times cited: 0) [PubMed] [BBR]
  13. Hsieh, J.-Y., Li, S.-Y., Chen, M.-C., Yang, P.-C., Chen, H.-Y., Chan, N.-L.*, Liu, J.-H.* and Hung, H.-C.* (2014, Jul.) Structural characteristics of the nonallosteric human cytosolic malic enzyme. Biochim. Biophys. Acta 1844, 1773-83. doi: 10.1016/j.bbapap.2014.06.019
    (SCI, IF 2018=2.540; Times cited: 8)
    *Co-corresponding authors [PubMed] [BBA] [PDB] [Proteopedia]
  14. Hsieh, J.-Y., Liu, J.-H., Yang, P.-C., Lin, C.-L., Liu, G.-Y. and Hung, H.-C. (2014, Jun.) Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme. PLoS ONE 9, e98385. doi: 10.1371/journal.pone.0098385
    (SCI, IF 2018=2.776; Times cited: 3) [PubMed] [PLoS ONE]
  15. Chepyshko, H., Lai, C.-P., Huang, L.-M., Liu, J.-H., and Shaw, J.-F. (2012, Jul.) Multifunctionality and diversity of GDSL esterase/lipase gene family in rice (Oryza sativa L. japonica) genome: new insights from bioinformatics analysis. BMC Genomics 13, 309. doi: 10.1186/1471-2164-13-309
    (SCI, IF 2018=3.501; Times cited: 62) [PubMed] [BMC Genomics]
  16. Hsieh, J.-Y., Liu, J.-H., Fang, Y.-W. and Hung, H.-C. (2009, May.) Dual roles of Lys57 at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme. Biochem. J. 402, 201-9. doi: 10.1042/BJ20090076
    (SCI, IF 2018=4.331; Times cited: 4) [PubMed] [Biochem J]
  17. Li, T.-N., Chin, K.-H., Liu, J.-H., Wang, A H.-J. and Chou, S.-H. (2009, May.) XC1028 from Xanthomonas campestris adopts a PilZ domain-like structure without a c-di-GMP switch. Proteins. 75, 282-8. doi: 10.1002/prot.22330
    (SCI, IF 2018=2.501; Times cited: 26) [PubMed] [Proteins] [PDB] [Proteopedia]
  18. Chou,C.-C., Chang, C.-W., Liu, J.-H., Chen, L.-F., Hsiao, C.-D. and Chen, H.-W. (2007, Jul.) Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a. J. Biol. Chem. 282, 27239-49. doi: 10.1074/jbc.M700351200
    (SCI, IF 2018=4.106; Times cited: 18) [PubMed] [JBC]
  19. Wang, C.-H.*, Liu, J.-H.*, Lee, S.-C., Wu, W.-g. and Hsiao, C.-D. (2006, Jan.) Glycosphingolipid-facilitated membrane insertion and internalization of cobra cardiotoxin: the sulfatide/cardiotoxin complex structure in a membrane-like environment suggests a lipid-dependent cell-penetrating mechanism for membrane binding polypeptides. J. Biol. Chem. 281, 656-77. doi: 10.1074/jbc.M507880200
    (SCI, IF 2018=4.106; Times cited: 48)
    *Co-first authors [PubMed] [JBC] [PDB] [Proteopedia]
  20. Liu, J.-H., Chang, T.-W., Huang, C.-Y., Chen, S.-U., Wu, H.-N., Chang, M.-C. and Hsiao, C.-D. (2004, Nov.) Crystal structure of PriB, a primosomal DNA replication protein of Escherichia coli. J. Biol. Chem. 279, 50465-71. doi: 10.1074/jbc.M406773200
    (SCI, IF 2018=4.106; Times cited: 35) [PubMed] [JBC] [PDB] [Proteopedia]
  21. Forouhar, F., Huang, W.-N., Liu, J.-H., Chien, K.-Y., Wu, W.-g. and Hsiao, C.-D. (2003, Jun.) Structural basis of the membrane-induced cardiotoxin A3 oligomerization. J. Biol. Chem. 278, 21980-8. doi: 10.1074/jbc.M208650200
    (SCI, IF 2018=4.106; Times cited: 69) [PubMed] [JBC] [PDB] [Proteopedia]
  22. Liu, J. H., Liao, Y. D. and Sun Y. J. (2001, Nov.) Crystallization and preliminary X-ray diffraction analysis of cytotoxic ribonucleases from bullfrog Rana catesbeiana. Acta Crystallogr. D57, 1697-9. doi: 10.1107/S0907444901013191
    (SCI, IF 2018=3.227; Times cited: 1) [PubMed] [Acta Cryst.]

研討會壁報

  1. Liu, J.-H., Lee, C.-Y., Lin, C.-C., Liu, Y.-L., Liu, G.-Y. and Hung, H.-C. (2017, May.) Molecular dynamics study on the interaction between dimer interface and substrate-binding site of human peptidylarginine deiminase 4. The 22th Biophysics Conference.
  2. Liu, J.-H. (2015, May.) Replica exchange molecular dynamics method for Trp-cage folding simulation in implicit solvent. The 20th Biophysics Conference.
  3. Peng, L.-W., Chen, Y.-T., and Liu, J.-H. (2014, Sep.) Crystallization of Dps protein from from Klebsiella oxytoca E718. The 20th NSRRC Users' Meeting.
  4. Lin, C.-W., Hung, H.-C., and Liu, J.-H. (2014, Sep.) Crystallization of human cytosolic NADP+-dependent malic enzyme complexed with cofactor and substrates. The 20th NSRRC Users' Meeting.
  5. Peng, L.-W., Chen, Y.-T., and Liu, J.-H. (2013, Sep.) Crystallization of β-lactamase like protein from Klebsiella oxytoca E718. The 19th NSRRC Users' Meeting.
  6. Li, J.-Y., Chen, C. K.-M., Chang, S.-W., Shaw, J.-F., Wang, A. H.-J., and Liu, J.-H. (2012, Oct.) Preliminary X-ray crystallographic analysis of trehalose synthase from Deinococcus radiodurans. The 18th NSRRC Users' Meeting.
  7. Chen, J.-W., Nien, C.-Y., Chen, C. K.-M., Chang, S.-W., Shaw, J.-F., Wang, A. H.-J., and Liu, J.-H. (2012, Oct.) Preliminary X-ray crystallographic analysis of trehalose synthase from Picrophilus torridus. The 18th NSRRC Users' Meeting.
  8. Nien, C.-Y., Cheng, C.-Y., Liu, J.-H., Shaw, J.-F., and Chen, Y.-T. (2012, May.) Crystal structure of glutaredoxin from Chlorella sorokiniana T-89. The 17th Biophysics Conference.
  9. Hung, S.-J. and Liu, J.-H. (2012, May.) Design of an accurate predictor for the thermostable protein design in PERT server. The 17th Biophysics Conference.
  10. Wu, J.-E., Chiu, S.-W., Yang, J.-Y., and Liu, J.-H. (2012, Mar.) Crystal structure of XopAI from Xanthomonas axonopodis pv. citri. 2012 International Conference on c-di-GMP and Xanthomonads.
  11. Hung, S.-J. and Liu, J.-H. (2011, Dec.) PERT: an integrated informatics platform for thermostable protein design. 2011 Taiwan Enzyme Mechanism Conference.
  12. Nien, C.-Y., Cheng, C.-Y., Shaw, J.-F., Chen, Y.-T., and Liu, J.-H. (2011, Oct.) Crystallization and preliminary X-ray crystallographic analysis of Chlorella glutaredoxin. The 17th NSRRC Users' Meeting.
  13. Wu, J.-E., Chiu, S.-W., Yang, J.-Y., and Liu, J.-H. (2010, Oct.) Crystallization and preliminary X-ray crystallographic analysis of XopAI from Xanthomonas axonopodis pv. citri. The 16th NSRRC Users' Meeting.
  14. Liu, J.-H., Hong, C.-S., Chang, S.-W., and Shaw, J.-F. (2009, Nov.) Investigation of the structural basis for thermostability of trehalose synthase from Picrophilus torridus. The 5th International Symposium on Biocatalysis and Biotechnology.
  15. Hsu, Y.-J. and Liu, J.-H. (2009, Oct.) Effects of trimethylamine-N-oxide (TMAO) on the interactions of lysozyme in crystal. The 15th NSRRC Users' Meeting.